12335MB IdeS or IdeZ Diagram showing cleavage site of IdeS and IdeZ Proteases. lgG1 Hinge Sequence: S-C-D-K-T-H-T-C-P-P-C-P-A-P-E-L-L-G-G-P-S-V IdeS or IdeZ cleavage site IdeS and IdeZ Proteases Give You: • Highly specific cleavage • Rapid generation of highly pure fragments • Fragments ready for therapeutic antibody characterization by LC/MS Core and Lower Hinge Sequence of Human and Mouse IgG Subclasses. IdeS or IdeZ Protease activity against each subclass is indicated. Cleavage of human IgGs by IdeS or IdeZ Protease has been previously shown to occur between two glycine residues, indicated in red. Subclass Human lgG1 lgG2 lgG3 lgG4 Mouse lgG1 lgG2a lgG2b lgG3 Hinge/CH2 Sequence CPPCPAPELLGGPSVF CPPCPAPP_VAGPSVF CPRCPAPELLGGPSVF AHHAQAPEFLGGPSVF PCICTVPEV___SSVF CPPCAAPNLLGGPSVF CHKCPAPNLEGGPSVF GSSCPAGNILGGPSVF IdeS Activity ++++ ++++ ++++ ++++ – + – + IdeZ Activity ++++ ++++ ++++ ++++ – ++++ – ++++ Learn More enews | November 2015 Pagina 8
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Labnet Oy - Promega's Monthly online Magazine - November 2015 edition Lees publicatie 101Home