IdeZ Diagram showing cleavage site of IdeZ Protease. lgG1 Hinge Sequence: S-C-D-K-T-H-T-C-P-P-C-P-A-P-E-L-L-G-G-P-S-V cleavage site IdeZ IdeZ Protease Gives You: • Highly specific cleavage • Rapid generation of highly pure fragments • Fragments ready for therapeutic antibody characterization by LC/MS Core and Lower Hinge Sequence of Human and Mouse IgG Subclasses. IdeZ Protease activity against each subclass is indicated. Cleavage of human IgGs by IdeZ Protease has been previously shown to occur between two glycine residues, indicated in red. Subclass Human lgG1 lgG2 lgG3 lgG4 Mouse lgG1 lgG2a lgG2b lgG3 Hinge/CH2 Sequence CPPCPAPELLGGPSVF CPPCPAPP_VAGPSVF CPRCPAPELLGGPSVF AHHAQAPEFLGGPSVF PCICTVPEV___SSVF CPPCAAPNLLGGPSVF CHKCPAPNLEGGPSVF GSSCPAGNILGGPSVF IdeZ Activity ++++ ++++ ++++ ++++ – ++++ – ++++ Learn More enews | January 2016 12335MC Pagina 6
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