Science Catalog 2012 Life Cell Signaling Drug Discovery Solutions Harnessing the Power of Bioluminescence for Biochemical & Cell-Based Assays VIABLE REDUCED VIABILITY NECROSIS APOPTOSIS Today’s drug development needs are mature and complex. Instead of targets, biology & workflow are key elements. Drug developers in academia and industry alike need assays that are sensitive, robust, scalable, and easy to use, all that fit their workflows while maintaining physiological relevance. No single assay can be applied to all phases of drug discovery but Promega has developed key platform technologies based on luminescence and fluorescence that can be applied across the discovery spectrum. From the well-defined biochemical assay to a phenotypic/’black box’ assay using genetic reporter assays, drug discovery assays span a complex spectrum of critical parameters and key deliverables. Promega continues to offer solutions that enable you to develop better drugs, faster: • Better profiling data • More biologically relevant data • Multiplexing solutions for increased understanding of biology • Custom Assay Services (CAS@promega.com) Starting with a single, well-defined biological reaction, we have developed a solid technology platform from which hundreds of unique in vitro biochemical & cellbased assays have been configured. On the following pages are multiple robust & validated assays for many early drug discovery needs. And if what you are looking for isn’t here, let us partner with you to develop a custom solution. 136 Custom Assay Services Biology-driven, Promega technology-enabled custom solutions for : • Cell Engineering • Assay Development & Qualification • Assay-Ready Cells In-Scale www.promega.com/CAS/ Reporter gene assays HO N S Promoter S N COOH Proliferation/viability assays HO N S Cellular enzymatic assays Protease HO S N Z-DEVD–N H N S S N proluciferin CO2H ATP ATP + ATP luc luciferase Glo ATP ATP ATP Lyse Cell S N COOH + ATP Ultra-Glo™ rLuciferase Glo S N COOH + ATP Ultra-Glo™ rLuciferase Glo For complete and up-to-date product information visit: www.promega.com/catalog 9541MA Pagina 139
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